I?B? Polyclonal Antibody

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Cat No: 13926

IκBζ is an ankyrin repeat-containing nuclear protein that is highly homologous to the IκB family member Bcl-3. Transcription of IκBζ is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, bu...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

antibodies I?B? IkBz I?Bz IkB? I?B-? I?B ? NF-?B NF?B NF ?B ankyrin-repeat-containing ankyrin repeats contains containing nuclear ptoreins homologous Bcl-3 Bcl Bcl3 3 three transcriptions up-regulated upregulated upregulation up-regulation up regulated regulation stimulation TLRs ligands IL-1 IL-6 IL1 IL6 IL 1 6 one six B-lymphocytes B lymphocytes Blymphocytes monocytes macrophages T-lymphocytes Tlymphocytes T fibroblasts endothelial cells p50 p65 recombinant inhibits inhibition inhibitors DNA binds binding heterodimer homodimer amino acids WB western blots blotting immunoblotting

Product Overview:
IκBζ is an ankyrin repeat-containing nuclear protein that is highly homologous to the IκB family member Bcl-3. Transcription of IκBζ is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkBz preferentially associates with the NF-κB subunit p50 rather than p65 and recombinant IκBζ proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	synthetic peptide corresponding to mouse IkB? amino acids 684-699 and 285-298
Application(s)	WB
Formulation	100 µg of protein G-purified IgG in 200 µl PBS, containing 0.2% gelatin and 0.05% sodium azide.
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.