I?B? (Phospho-Ser32/36) Monoclon

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I?B? (Phospho-Ser^32/36) Monoclonal Antibody (Clone 39A1413)

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Cat No: 13923

NF-κB is silenced in the cytoplasm by an inhibitory protein IκB.{18565} Synthesis of IκBα is autoregulated.{18566} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18543,18544,185...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

antibodies I?B? IkBa I?Ba IkB? I?B-? I?B ? intracellular western blots blotting immunoblotting WB NF-?B NF?B NF ?B slienced slience inhibitory inhibits inhibition inhibitor proteins asutoregulated auto-regulated auto regulated regulates phosphorylated kinase complex IKK IKK1 IKK2 IKK3 IKK-1 IKK-2 IKK-3 1 2 3 IKK1/a IKK1-a IKK1a IKK2/b IKK2-b IKK2b IKK3/g IKK3-g IKK3g degradation phosphorylation dimers translocates nucleus genes target immunoprecipitation IP serines serine32 serine36 serine-32 serine-36 32 36 ser32 ser36 ser-32 ser-36 ser genes regulation inflammation signal transduction

Product Overview:
NF-κB is silenced in the cytoplasm by an inhibitory protein IκB.{18565} Synthesis of IκBα is autoregulated.{18566} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18543,18544,18545,18540} External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IκB-kinase complex that specifically phosphorylates IκBa on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IκBα and subsequent degradation by the 26S proteasome. Degradation of IκBα results in unmasking of the nuclear localization signal of NF-κB dimers, which subsequently translocate to the nucleus and activate target genes.{18541,18542} Six members of the IκB family members have been identified.{18565} one of the first genes induced following NF-κB activation is IκBα.

Size	1 ea
Shipping	dry ice
Host	Mouse
Antigen	synthetic peptide containing phosphorylated serine residues corresponding to human I?B? amino acids 32 and 36
Clone	39A1413
Isotype	IgG1?
Application(s)	WB and IP
Formulation	100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% gelatin and 0.05% sodium azide
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

I?B? (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)