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Methylpiperidino pyrazole

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    Methyl<wbr/>piperidino pyrazole
  • Methyl<wbr/>piperidino pyrazole
Cat No: 13863
Biochemicals - Receptor Pharmacology
Cayman

Estrogen action is mediated through two estrogen receptor (ER) subtypes, ERα and ERβ, which have distinct target tissue distributions and functional activities.{10559} Methylpiperidino pyrazole is an ER antagonist that is highly selective for ERα compa...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazol-3-yl]-phenol
Correlated keywords:
  • estrogen ER? receptors ER? antagonists SERM transcription cancers methyl-piperidino piperidino methyl ERs ER-? ERa ER-a ER.alpha. ER-.alpha. ERalpha ER-alpha ER-? ERb ER-b ERbeta ER-beta ER.beta. ER-.beta. inhibits inhibitions inhibitors transcriptional estrogen-responsive
Product Overview:
Estrogen action is mediated through two estrogen receptor (ER) subtypes, ERα and ERβ, which have distinct target tissue distributions and functional activities.{10559} Methylpiperidino pyrazole is an ER antagonist that is highly selective for ERα compared to ERβ (Kis = 5.6 nM and 2.3 μM, respectively).{21951} It can inhibit ERα transcriptional activation with an IC50 value of 80 nM.{21949} It has been used to evaluate the role of ERα in various estrogen-responsive systems, including certain cancers.{21950}
Size 5 mg
Shipping dry ice
CAS Number 289726-02-9
Molecular Formula C29H31N3O3
SMILES CC1=C(C2=CC=C(OCCN3CCCCC3)C=C2)N(C4=CC=C(O)C=C4)N=C1C5=CC=C(O)C=C5
Molecular Weight 469,6
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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