GW 1929

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GW 1929

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Cat No: 13689

Biochemicals - Receptor Pharmacology

Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism.{15751} The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone (Item N...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine

Correlated keywords:

receptors agonists PPARs diabetes metabolic syndromes nuclear neurosciences inflammation PPAR? PPARg PPARgamma PPAR.gamma. PPAR-? PPAR-g PPAR-gamma PPAR-.gamma. ? g gamma .gamma. peroxisomes proliferator-activated proliferator activated non-thiazolidinedione activator activates activation GW1929 GWs 1929 GW-1929 anti-hyperglycemic anti-hyperlipidemic hyperglycemic hyperlipidemic anti thiazolidinedione non nonthiazolidinedione antihyperlipidemic antihyperglycemic type 2

Product Overview:
Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism.{15751} The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone (Item No. 71750) and rosiglitazone (Item No. 71740).{8461} GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes.{25251} It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes.{25251,25253} Both in vitro and in vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone.{25251,25253} In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.{25252}

Size	1 mg
Shipping	dry ice
CAS Number	196808-24-9
Molecular Formula	C₃₀H₂₉N₃O₄
SMILES	O=C(C1=CC=CC=C1)C(C=CC=C2)=C2N[C@H](C(O)=O)CC3=CC=C(OCCN(C4=CC=CC=N4)C)C=C3
Molecular Weight	495,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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