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Alfuzosin (hydrochloride)

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    Alfuzosin (hydro<wbr>chloride)
  • Alfuzosin (hydro<wbr>chloride)
Cat No: 13648
Biochemicals - Receptor Pharmacology
Cayman

Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).{18261,18269} It displays high-affinity with non-selectivity for the three known hu...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide, monohydrochloride
Correlated keywords:
  • ?1-adrenergic receptors antagonists lower urinary tract symptoms benign prostatic hyperplasia BPH adrenoceptors ?1A ?1B ?1D contractions smooth muscles antihypertensives vasodilators urinary flow 133880-44-1 Urion Alfoten SL 77-499-10 anti-hypertensives alpha 1 .alpha.1 Xatral Quinazolines
Product Overview:
Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).{18261,18269} It displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively).{18268} Consistent with a role for α1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.{18261} In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.{18269} Alfuzosin produces minimal vasodilatory and sexual function side effects.{18262,18266,18267}
Size 5 mg
Shipping dry ice
CAS Number 81403-68-1
Molecular Formula C19H27N5O4 • HCl
SMILES COC1=CC2=C(C(N)=NC(N(C)CCCNC(C3CCCO3)=O)=N2)C=C1OC.Cl
Molecular Weight 425,9
Formulation A crystalline solid
Purity ≥98%
Custom Code 2918.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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