AL 6598

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AL 6598

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Cat No: 13620

Biochemicals - Receptor Pharmacology

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]-2-buten-1-yl]oxy]-1-methylethyl ester, acetic acid

Correlated keywords:

intraocular pressures IOPs glaucoma PGD2 agonists DP receptors eyes hypertension F2 alpha Prostaglandin Prostaglandin F2 alpha F2alpha Prostaglandin Prostaglandin F2alpha 9alpha,11beta-PGF2 9alpha,11beta PGF2 Prostaglandin F2 Enzaprost F alpha, PGF2 PGF2 alpha PGF2alpha Dinoprost Estrofan PGF2

Product Overview:
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay.{9839} Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.{9839}

Size	500 µg
Shipping	dry ice
CAS Number	170291-06-2
Molecular Formula	C₂₃H₃₉ClO₅
SMILES	Cl[C@H]1[C@H](C/C=C\COCC(OC(C)C)=O)[C@@H](CC[C@@H](O)C2CCCCC2)[C@H](O)C1
Molecular Weight	431
Formulation	A solution in methyl acetate
Purity	≥97%
Custom Code	2915.60
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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