IWR-1-exo

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IWR-1-exo

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Cat No: 13598

Biochemicals - Wnt Signaling

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-benzamide

Correlated keywords:

Wnt cancers embryonic developments tissues homeostasis embryogenesis tumorigenesis stem cells ?-catenin genes expressio Cellobiohydrolase, 1,4-beta-D-Glucan 1,4-beta-D-Glucan Cellobiohydrolase 1,4 beta D Glucan Cellobiohydrolase 1,4-beta-Cellobiosidase, Cellulose Cellulose 1,4-beta-Cellobiosidase Cellulose 1,4 beta Cellobiosidase Beta-Glucancellobiohydrolase Beta Glucancellobiohydrolase Exo-Cellobiohydrolase Exo Cellobiohydrolase Cellobiohydrolase II Cellobiohydrolase I Cellobiohydrolase A Cellobiohydrolase Exoglucanase II CEL1 Protein CbhI Proteinn transcription inhibitors inhibits inhibition controls

Product Overview:
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis,{17947} and tumorigenesis.{14336,13185} Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-exo is a diastereomer of IWR-1-endo, the potent inhibitor of the Wnt response.{17505} Whereas IWR-1-endo strongly blocks cell-based Wnt/β-catenin pathway reporter response (IC50 = 180 nM){17505} and suppresses Wnt-dependent zebrafish tail fin regeneration (0.5 μM),{17948} IWR-1-exo has little effect in either assay at 10 μM.{17505} Thus, this compound is an ideal control for tests involving the active form, IWR-1-endo.

Size	5 mg
Shipping	dry ice
CAS Number	1127442-87-8
Molecular Formula	C₂₅H₁₉N₃O₃
SMILES	[H][C@]12[C@](C(N(C3=CC=C(C(NC4=CC=CC5=C4N=CC=C5)=O)C=C3)C2=O)=O)([H])[C@@H]6C=C[C@H]1C6
Molecular Weight	409,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2916.31
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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