FIPI - C23H24FN5O2 - Bertin Bioreagent

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FIPI

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Cat No: 13563

Biochemicals - Small Molecule Inhibitors

Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle tra...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide

Correlated keywords:

Phospholipases D PLD phosphatidic acids PA Ras activation cells spreading stress fiber formation chemotaxis membrane vesicles trafficking halopemide inhibitors inhibits inhibition PLD1 PLD2 F-actin cytoskeletons inflammation arthritis Pharmascience Brand of Domperidone Maleate Stadapharm Brand of Domperidone Maleate Ratiopharm Brand of Domperidone Maleate Taxandria Brand of Domperidone Maleate Novopharm Brand of Domperidone Maleate Nu-Pharm Brand of Domperidone Maleate Nu Pharm Brand of Domperidone Maleate Apotex Brand of Domperidone Maleate Hexal Brand of Domperidone Maleate Aliud Brand of Domperidone Maleate Teva Brand of Domperidone Maleate Pierre Fabre Brand of Domperidone Gry Brand of Domperidone Maleate Rottapharm Brand of Domperidone Monohydrochloride, Domperidone Domperidone Monohydrochloride Janssen Brand of Domperidone Domperidone Maleate (1:1) Maleate, Domperidone Domperidone Maleate Gamir Domperidona Stada Domperidon ratio-Domperidone ratio Domperidone Hexal Domperidon Domperidona Gamir Novo-Domperidone Novo Domperidone Domperidon Stada Domperidon Hexal PMS-Domperidone PMS Domperidone Domperidon-TEVA Domperidon TEVA Apo-Domperidone Apo Domperidone Nu-Domperidone Nu Domperidone Domperidon AL Domperidone Gastrocure Domperidon R-33,812 Nauzelin Motilium R-33812 R33,812 Péridys Domidon R33812

Product Overview:
Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM).{17399,17462} It also prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.{17399} FIPI has good pharmacokinetic parameters in rats, with a half-life greater than five hours, a Cmax that, at 363 nM, is greater than 10-fold the IC50 versus PLD2, and bioavailability of 18%.{17462}

Size	1 mg
Shipping	dry ice
CAS Number	939055-18-2
Molecular Formula	C₂₃H₂₄FN₅O₂
SMILES	O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3
Molecular Weight	421,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.