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Fatostatin (hydrobromide)

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    Fatostatin (hydro<wbr>bromide)
  • Fatostatin (hydro<wbr>bromide)
Cat No: 13562
Biochemicals - Small Molecule Inhibitors
Cayman

Sterol regulatory element binding proteins (SREBPs) are transcription factors that have pivotal roles in lipogenesis and fat metabolism.{15316} The activation of SREBPs requires escort to the Golgi by SREBP cleavage-activating protein (SCAP) followed b...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-pyridine, hydrobromide
Correlated keywords:
  • 125256-00-0 inhibitors metabolism diabetes obesity cancers intracellular signaling transcription factors signals transduction inhibits sterols regulatory elements binding proteins SREBPs lipogenesis fats cleavage-activating cleavage activating SCAP SREBP-1 SREBP 1 one SREBP-one SREBP-2 SREBP 2 two SREBP-two adipogenesis insulin-induced insulin induced insulin-like like growth factor 1 one IGF1 IGFone IGF lipids A
Product Overview:
Sterol regulatory element binding proteins (SREBPs) are transcription factors that have pivotal roles in lipogenesis and fat metabolism.{15316} The activation of SREBPs requires escort to the Golgi by SREBP cleavage-activating protein (SCAP) followed by proteolytic release of SREBP from the Golgi.{15551} Fatostatin is an inhibitor of SREBP activation, preventing SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC50 = 5.6 µM).{17397,23867} This blocks constitutive SREBP-mediated gene expression in the human prostate cancer cell line DU145.{17397} Fatostatin prevents insulin-induced adipogenesis of 3T3-L1 cells as well as growth induced by insulin-like growth factor 1 in DU145 cells (IC50 = 0.1 µM).{23869} Through its actions on SCAP/SREBP-1, it inhibits high glucose-induced upregulation of TGF-β in primary rat mesangial cells.{23868} This compound also alters lipid metabolism in vivo, reducing hepatic fat accumulation in ob/ob mice.{17397}
Size 5 mg
Shipping dry ice
CAS Number 298197-04-3
Molecular Formula C18H18N2S • HBr
SMILES CC(C=C1)=CC=C1C2=CSC(C3=CC(CCC)=NC=C3)=N2.Br
Molecular Weight 375,3
Formulation A crystalline solid
Purity ≥95%
Custom Code 2933.49
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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