N-methyl Leukotriene C4

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N-methyl Leukotriene C₄

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Cat No: 13390

Biochemicals - Lipids

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.{781} It is one of the co...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-methyl-5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

Correlated keywords:

allergy allergies asthma anaphylaxis SRS-A cysteinyl leukotrienes LTs mimetics

Product Overview:
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult.{1251} N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.{16001}It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively.{18790} It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.{18790}

Size	25 µg
Shipping	dry ice
CAS Number	131391-65-6
Molecular Formula	C₃₁H₄₉N₃O₉S
SMILES	CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(C(=O)NCC(=O)O)[N]1(NC)C(=O)CCC1C(=O)O)[C@@H](O)CCCC(=O)O
Molecular Weight	639,8
Formulation	A solution in ethanol
Purity	≥97%
Custom Code	2937.50
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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