TPEN - C26H28N6 - Bertin Bioreagent

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TPEN

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Cat No: 13340

Biochemicals - Metal Chelators

As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.{18326} Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and diffe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine

Correlated keywords:

zinc apoptosis hypoxic pulmonary vasoconstrictions cells proliferation differentiation caspases transition metals chelators cancers intracellular extracellular intracellular extra- intra- extra cellular ions concentrations vasoconstrictiors

Product Overview:
As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.{18326} Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.{18327} At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation.{18324} At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.{18325}

Size	10 mg
Shipping	dry ice
CAS Number	16858-02-9
Molecular Formula	C₂₆H₂₈N₆
SMILES	c1ccc(nc1)CN(CCN(Cc1ccccn1)Cc1ccccn1)Cc1ccccn1
Molecular Weight	424,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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