MS-275

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MS-275

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Cat No: 13284

Biochemicals - Small Molecule Inhibitors

MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester

Correlated keywords:

inhibitors histones deacetylases HDACs HDAC1 HDAC3 HDAC8 cyclin-dependent kinases inhibitor 1A p21 CIP1 WAF1 cells growth differentiation tumors cancers apoptosis adriamycin PARP Hsp90 ms275 MS 27-275 SNDX-275 SNDX275 MS27275 genes regulations

Product Overview:
MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}

Size	1 mg
Shipping	dry ice
CAS Number	209783-80-2
Molecular Formula	C₂₁H₂₀N₄O₃
SMILES	O=C(NCC1=CC=C(C(NC2=C(N)C=CC=C2)=O)C=C1)OCC3=CC=CN=C3
Molecular Weight	376,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.