Splitomicin

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Splitomicin

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Cat No: 13168

Biochemicals - Small Molecule Inhibitors

Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. S...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one

Correlated keywords:

sirtuins Sir2p Sir-2p Sir 2p SIR2 NAD NAD+-dependent NAD-dependent dependent histone deacetylase activity activities genes regulations lifespan life-span life span yeast expression DNA replication inhibitor inhibits inhibition Hst1 Hst-1 Hst 1 HDACs chromatin research epigenetics regulation modification Sirs small molecules Pyrones

Product Overview:
Sir2p, the product of the SIR2 gene, is a conserved NAD+-dependent histone deacetylase (HDAC) involved in the regulation of the lifespan in yeast. It plays roles in silencing gene expression and negatively regulates the initiation of DNA replication. Splitomicin is a small molecule inhibitor of Sir2p histone deacetylase activity, displaying higher activity in vivo (minimal inhibitory concentration = 0.49 µM) than in vitro (IC50 = 60 µM).{18318,18319,18320} It less effectively inhibits yeast Hst1, a paralog of Sir2p.{18319} Splitomicin has diverse effects on mammalian cells.{18321,18322,18323}

Size	1 mg
Shipping	dry ice
CAS Number	09/03/5690 00:00
Molecular Formula	C₁₃H₁₀O₂
SMILES	O=C1CCc2c(ccc3ccccc23)O1
Molecular Weight	198,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.