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AT-56

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    AT-<wbr/>56
  • AT-<wbr/>56
Cat No: 13160
Biochemicals - Small Molecule Inhibitors
Cayman

Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine
Correlated keywords:
  • Prostaglandins D synthases L-PGDS PGD2 lipocalin-type inflammation inhibition inhibitors inhibits PGs eosinophils LPGDs bronchoalveolar lavage fluid Lysosomal Proton Translocating ATPases Vacuolar Proton-Translocating ATPases Vacuolar Membrane H(+)-ATPase Proteins Membrane-Associated Membrane-Associated Proteins Membrane Associated Proteins Tacrolimus Binding Proteins Proteins Rapamycin-Binding Proteins Integral Membrane Membrane Proteins Integral Binding Proteins Rapamycin Rapamycin-Binding Proteins Rapamycin Binding Proteins Protein Integral Membrane Integral Membrane Proteins Vacuolar F(1)F(0) ATPasesLysosomal F(1)F(0) ATPase Integral Membrane Protein Vacuolar F(1)F(0) ATPase Proteins Cell Membrane Protein FK-506-Binding Proteins Cell Surface Protein FK506-Binding FK-506-Binding ProteinFK506 Binding Proteins FK 506 Binding Protein Cell Membrane Proteins FK506-Binding ProteinFK506 Binding Protein Cell Surface Proteins H+-ATPase, Vacuolar Vacuolar H+-ATPase Vacuolar H+ ATPase Proteins Membrane Proteins Vacuolar ATPase Rotamase FKBP V Type ATPase FKBP Rotamase Membrane FKBP
Product Overview:
Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (β-trace, L-PGDS) and the hematopoietic-type enzyme (H-PGDS).{8448,9588,12044} L-PGDS is localized in the central nervous system, male genital organs of various mammals, and the human heart and is a major protein in human cerebrospinal fluid (CSF).{8448} AT-56 is a selective, competitive, and highly bioavailable inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with a Ki value of 75 µM.{16647} It inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse cells with an IC50 value of 95 µM.{16647} At concentrations as high as 100 µM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2.{16647} At 10 mg/kg AT-56, the numbers of total cells, infiltrating eosinophils, and monocytes in bronchoalveolar lavage fluid of L-PGDS transgenic mice were decreased to 23, 6, and 41% of controls, respectively.{16647}
Size 1 mg
Shipping dry ice
CAS Number 162640-98-4
Molecular Formula C25H27N5
SMILES C12=C(C=CC=C2)C=CC3=C(C=CC=C3)/C1=C4CCN(CCCCC5=NN=NN5)CC\4
Molecular Weight 397,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2933.39
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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