Bertin Bioreagent
You are here :
- Bioreagent /
- Search Products /
- Products /
- Supplier /
- Cayman /
- Sodium Butyrate
Sodium Butyrate
-
Zoom
Cat No: 13121
Biochemicals
- Lipids
Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylas...
MoreThis product can only be bought through Cayman Chemical. Please contact us.
Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
- butanoic acid, sodium salt
Correlated keywords:
- fatty acids short chains inhibitors inhibits inhibition histones deacetylases HDACs epigenetics growth arrest differentiation apoptosis cancers inflammation genes expressions pro-inflammatory proinflammatory cytokines IFN-? IL-6 IFN? IL6 IL-1? IL1? IFNg regulations
Product Overview:
Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Sodium butyrate also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}
Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Sodium butyrate also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}
| Size | 50 g |
| Shipping | room temp. |
| CAS Number | 156-54-7 |
| Molecular Formula | C4H7O2 • Na |
| SMILES | CCCC([O-])=O.[Na+] |
| Molecular Weight | 110,1 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| Custom Code | 2915.60 |
| UNSPSC code | 12352100 |
Click here to ask for your quote and get 15% off Cayman's products.
Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
/
We also advise you
Cross selling for this product : Sodium Butyrate There are 10 products.
Follow Us
Contact us
Any project? Any challenge? We are in!
+33 (0)139 306 036
Any questions?
Contact us
Headquarters :
Parc d’Activités du Pas du Lac
10 bis avenue Ampère
78180 Montigny le Bretonneux - France
View our other locations
Bertin Bioreagent
Copyright © Bertin Bioreagent - All rights reserved
Made by 
Loading...