Mithramycin A

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Mithramycin A

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Cat No: 11434

Biochemicals - Natural Products

Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1S)-5-deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-?-D-arabino-hexopyranosyl)-?-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-?-D-ribo-hexopyranosyl-(1?3)-O-2,6-dideoxy-?-D-lyxo-hexopyranosyl-(1?3)-2,6-dideoxy-?-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose

Correlated keywords:

1395-17-1 1403-98-1 12708-66-6 12708-67-7 23973-19-5 97666-60-9 219612-19-8 744999-90-4 807260-73-7 826336-23-6 899900-19-7 1195235-16-5 mithracin NSC-24559 NSC24559 PA144 PA-144 A2371 A-2371 plicatomycin anti-tumors neuroprotective antibiotics chemotherapeutics histones acetylation transcription factors chromatin regulation Sp1 inhibitors inhibits inhibition oncogene TRAIL cancers Streptomyces grieseus S. grieseus DNA apoptosis

Product Overview:
Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression.{20905,20901} Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.{20904,20903,20902}

Size	1 mg
Shipping	dry ice
CAS Number	18378-89-7
Molecular Formula	C₅₂H₇₆O₂₄
SMILES	O=C1C2=C(O)C3=C(O)C(C)=C(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O[C@@H]5O[C@H](C)[C@@H](O)[C@H](O)C5)C4)C=C3C=C2C[C@]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)([H])[C@@H]1O[C@@H]6O[C@H](C)[C@@H](O)[C@H](O[C@@H]7O[C@H](C)[C@H](O)[C@H](O[C@@H]8O[C@H](C)[C@@H](O)[C@@](C)(O
Molecular Weight	1085,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.