tetranor-PGDM

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tetranor-PGDM

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Cat No: 12850

Biochemicals - Lipids

Prostaglandin D2 (PGD2; Item No. 12010) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} PGD2 is also produced in the brain by lipocalin-PGD-syn...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9?-hydroxy-11,15-dioxo-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid

Correlated keywords:

metabolites urinary PGD2 prostaglandins D2 urine PGD-M t-PGDM t-prostaglandin

Product Overview:
Prostaglandin D2 (PGD2; Item No. 12010) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine.{15162} The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α (Item No. 16530), a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.{15162}

Size	25 µg
Shipping	dry ice
CAS Number	70803-91-7
Molecular Formula	C₁₆H₂₄O₇
SMILES	O[C@@H]1[C@H](CCC(O)=O)[C@@H](CCC(CCCCC(O)=O)=O)C(C1)=O
Molecular Weight	328,4
Formulation	A solution in methanol
Purity	≥90%
Custom Code	2932.99
UNSPSC code	12352100

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MSDS

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