Butyrolactone 3

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Butyrolactone 3

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Cat No: 12095

Biochemicals - Small Molecule Inhibitors

Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits the histone acetyltransferase G...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid

Correlated keywords:

butyrolactone-3 Gcn5 chromatin modification HAT histones H3 spliceosome pre-mRNA splicing acetyltransferase Gcn-5 Gcn 5 MB3 MB-3 MB 3 inhibitors inhibits inhibitions PCAF pre-mRNA mRNA

Product Overview:
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits the histone acetyltransferase Gcn5 with an IC50 value of 100 μM and has an affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.{21590} Butyrolactone 3 can inhibit pre-RNA splicing with an IC50 value of 0.5 mM and as such has been used to investigate Gcn5/PCAF-like HAT functions during assembly of spliceosome before pre-mRNA translation.{21589}

Size	1 mg
Shipping	dry ice
CAS Number	778649-18-6
Molecular Formula	C₉H₁₂O₄
SMILES	O=C1C([C@@H](C(O)=O)[C@H](CCC)O1)=C
Molecular Weight	184,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2916.39
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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