Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

1,24-dihydroxy Vitamin D3 (hydrate)

  • Zoom
    1,24-<wbr/>dihydroxy Vitamin D<sub>3</sub> (hydrate)
  • 1,24-<wbr/>dihydroxy Vitamin D<sub>3</sub> (hydrate)
Cat No: 12079
Biochemicals - Receptor Pharmacology
Cayman

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.{15096,19429} In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and ...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol, monohydrate
Correlated keywords:
  • 131801-95-1 PRI2191 PRI-2191 TV02 TV-02 vitamins D psoriasis lymphocytes T cells RANTES IL-8 keratinocytes T-cells D3 analogs 1,25-dihydroxy ointment phototherapy ultraviolet lights inhibits inhibition inhibitors receptors dermal fibroblasts cutaneous lymphocyte antigens CD4 57333-96-7
Product Overview:
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.{15096,19429} In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes.{21611} 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 μg/g ointment, safely and effectively suppresses psoriasis.{21613} It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis.{21615} 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor.{21614} It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration.{21612,21610}
Size 500 µg
Shipping dry ice
CAS Number 93129-94-3
Molecular Formula C27H44O3 • H2O
SMILES C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](O)C(C)C)([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C.O
Molecular Weight 434,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2936.29
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : 1,24-<wbr/>dihydroxy Vitamin D<sub>3</sub> (hydrate) There are 10 products.

Search