Biphenylindanone A

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Biphenylindanone A

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Cat No: 11986

Biochemicals - Receptor Pharmacology

The metabotropic glutamate receptor 2 (mGluR2) is a Gi/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA.{21987} Biphenylindanone A (BINA) is a positive allosteri...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid

Correlated keywords:

MRLSD230 MRLSD-230 receptors glutamate metabotropic receptors mGluR2 neurosciences psychosis schizophrenia drugs addictions biphenyl-indanone A biphenyl indanone Gi/o cells tissues animals in vivo brains penetrance elucidate allosteric modulator

Product Overview:
The metabotropic glutamate receptor 2 (mGluR2) is a Gi/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA.{21987} Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC50 values of 33.2 and 96 nM, respectively.{21984} It has no effect on glutamate-induced activation of other mGluR types.{21984} BINA can be used on cells, tissues, or animals.{21984,21983} Because of its selectivity for mGluR2, robust in vivo activity, and brain penetrance, BINA can be used to elucidate the role of mGluR2 in such diverse processes as psychosis, schizophrenia, and drug addiction.{21982,21985,21986}

Size	5 mg
Shipping	dry ice
CAS Number	866823-73-6
Molecular Formula	C₃₀H₃₀O₄
SMILES	CC1=C(C)C2=C(CC(C3CCCC3)C2=O)C=C1OCC4=CC(C5=CC=C(C(O)=O)C=C5)=CC=C4
Molecular Weight	454,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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MSDS

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