(R,S)-BHFF

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(R,S)-BHFF

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Cat No: 25535

Biochemicals - Receptor Pharmacology

(R,S)-BHFF is a positive allosteric modulator of GABAB receptors that increases the potency of GABA by 15.3-fold in a GTPγ[35S] binding assay when used at a concentration of 0.3 μM.{42368} It is selective for GABAB over a panel of receptors and ion ch...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,7-bis(1,1-dimethylethyl)-3-hydroxy-3-(trifluoromethyl)-2(3H)-benzofuranone

Correlated keywords:

GTP-? CCK-A CA-1 GABA-B Gamma-Amino Butyric acid

Product Overview:
(R,S)-BHFF is a positive allosteric modulator of GABAB receptors that increases the potency of GABA by 15.3-fold in a GTPγ[35S] binding assay when used at a concentration of 0.3 μM.{42368} It is selective for GABAB over a panel of receptors and ion channels at 10 μM, however, it inhibits the cholecystokinin-1 (CCKA) receptor (IC50 = 4.1 μM). (R,S)-BHFF enhances inhibition of the population spike of CA1 pyramidal cells induced by the GABAB receptor antagonist baclofen (Item No. 18600) in rat hippocampal slices. In vivo, (R,S)-BHFF increases the baclofen-induced loss of righting reflex and reverses stress-induced hyperthermia in mice. (R,S)-BHFF (50, 100, and 200 mg/kg) reduces the number of lever responses to alcohol by 30, 65, and 90%, respectively, and increases latency to the first response on the alcohol lever in Sardinian alcohol preferring (sP) rats when administered pre-conditioning at a dose of 200 mg/kg.{42369}

Size	5 mg
Shipping	dry ice
CAS Number	123557-91-5
Molecular Formula	C₁₇H₂₁F₃O₃
SMILES	CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1
Molecular Weight	330,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.20
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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