Dorsomorphin

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Dorsomorphin

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Cat No: 11967

Biochemicals - Kinase Inhibitors

Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone m...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine

Correlated keywords:

compound-C inhibitors inhibits inhibitions AMPKs bones morphogenetics proteins types 1 type-1 ones receptors BMP ACTR-I ACTRs ACTRI ACRTs I ALK2 BMPR-IA ALK3 BMPR-IB ALK 6 Akt/mTOR autophagy cancers ALKs ALK-2 ALK-3 ALK-6 2 3 6 two three six BMPRIA BMPR s IA IB BMPRIB Akt mTOR potent selective reversible activity kinases doses denpendents dose-dependently dose-dependents downregulate pathways induces U251 humans glioma cells U-251 U 251 BML275

Product Overview:
Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin at 10 μM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}

Size	5 mg
Shipping	dry ice
CAS Number	866405-64-3
Molecular Formula	C₂₄H₂₅N₅O
SMILES	N1(CCOC2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC=C5)C=N4)C=C2)CCCCC1
Molecular Weight	399,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.59
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.