A-769662

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A-769662

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Cat No: 11900

Biochemicals - Receptor Pharmacology

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.{22445,22447} A-769662 specifically activate...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Correlated keywords:

obesity syndromes kinases diabetes atherosclerosis AMP-activated proteins kinases AMPK lipids metabolisms glucose metabolic stress activators activates active glucose uptakes diseases A769662 A-769662 A 769662 A769,662 A 769,662 A-792,662 thienopyridone inhibits inhibiting inhibitions inhibitors CYP450 fatty acids oxidations adipocytes differentiations uptake up-take alpha .alpha. a beta .beta. b gamma .gamma. g heterotrimers sensors regulates regulating cells cellular energy homeostasis small molecules thienopyridones cell-free assays intact allosterically Thr172 stimulates CYP450-mediated cytochromes P450 dephosphorylations skeletal muscles endothelium endothelial

Product Overview:
A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172.{22445,22447} A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK.{22445,22448} A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.{22448,22444,22450,22449,22446}

Size	5 mg
Shipping	dry ice
CAS Number	844499-71-4
Molecular Formula	C₂₀H₁₂N₂O₃S
SMILES	OC1=CC=CC=C1C2=CC=C(C3=CSC(N4)=C3C(O)=C(C#N)C4=O)C=C2
Molecular Weight	360,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2837.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.