2-Trifluoromethyl-2'-methoxychal

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2-Trifluoromethyl-2'-methoxychalcone

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Cat No: 11881

Biochemicals - Small Molecule Activators

Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2E-propen-1-one

Correlated keywords:

Nrf2 antioxidant response elements ARE oxidative stress inflammation Keap1 activator anti-cancer anti-inflammatory GCLM NQO1 activators activate active Nrf-2 Nrfs 2 Keap-1 Keaps 1 anticancer antiinflammatory in vitro bronchial epithelial cells Beas-2B Beas2B Beas 2B small intestines

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Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice.{21374} Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine.{21374}

Size	5 mg
Shipping	dry ice
CAS Number	1309371-03-6
Molecular Formula	C₁₇H₁₃F₃O₂
SMILES	COC1=C(C(/C=C/C2=CC=CC=C2C(F)(F)F)=O)C=CC=C1
Molecular Weight	306,3
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

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