Prostaglandin Transporter (C-Ter

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Prostaglandin Transporter (C-Term) Polyclonal Antibody

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Cat No: 11860

Prostaglandins (PGs) are signaling molecules that modulate physiological or pathologic functions such as platelet aggregation, vascular tone, gastric cytoprotection, uterine contraction, inflammation, cancer and Alzheimer’s disease.{310,1606,3947,9898...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

prostaglandins PGs SLCO2A1 platelet aggregation vascular tone inflammation cancers Alzheimer's western blots blotting immunofluorescence immunocytochemistry Solute Carrier Organic Anion Transporter Family Member 2A1 ICCWB gastric cytoprotection IFC uterine contractions transporters

Product Overview:
Prostaglandins (PGs) are signaling molecules that modulate physiological or pathologic functions such as platelet aggregation, vascular tone, gastric cytoprotection, uterine contraction, inflammation, cancer and Alzheimer’s disease.{310,1606,3947,9898,10008,11300} PG transporter (PGT) is generally expressed in endothelial and epithelial cells. Transport of extracellular PGs into cells occurs via a specific PGT, allowing PG oxidation by 15-hydroxy PG dehydrogenase or binding with their respective receptor(s).{1917,3471,21013} Cayman’s peptide-affinity purified PGT polyclonal antibody detects a 71 kDa band on WB. Loss of PGT detection may occur due to cell membrane aggregation during exposure of some samples to high temperature processing.{21648} Therefore treatment of the protein sample at 37°C for 15 minutes (water bath or heating block), and if desired, in parallel with another aliquot at 95°C is recommended prior to electrophoresis and blotting. When using the antibody for ICC or IF, cell permeabilization is necessary due to the intracellular location of the antibody binding site (C-terminal amino acids).

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	A synthetic peptide from the C-terminal region of human PGT
Application(s)	WB
Formulation	500 µl of peptide affinity purified polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.