INK128

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INK128

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Cat No: 11811

Biochemicals - Kinase Inhibitors

INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM).{31895,21344,21346} It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2.{21344} INK128 interferes with the growth of cell l...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Correlated keywords:

mTOR PI3K rapamycin TORC-1/2 TORC1/2 TORC1 TORC-1 1 TORC2 TORC-2 mammalian target INK-128 sapanisertib MLN-0128 MLN128 MLN-128 m-TOR PI3-K phosphatidylinositol 3-kinase phosphoinositide complex panPI3K

Product Overview:
INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM).{31895,21344,21346} It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2.{21344} INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors.{21344,21345} Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models.{21344} The effects of INK128 on gene expression also reduce invasion and metastasis.{20985}

Size	1 mg
Shipping	dry ice
CAS Number	1224844-38-5
Molecular Formula	C₁₅H₁₅N₇O
SMILES	CC(C)N1C2=NC=NC(N)=C2C(C3=CC(N=C(N)O4)=C4C=C3)=N1
Molecular Weight	309,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.59
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.