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Vinblastine (sulfate)

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    Vinblastine (sulfate)
  • Vinblastine (sulfate)
Cat No: 11762
Biochemicals - Natural Products
Cayman

Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its c...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • vincaleukoblastine, monosulfate
Correlated keywords:
  • inhibits inhibitors cells cycles biology cancers inhibitions vinca rosea alkaloid antimicrotubule drugs cancers hodgkins lymphoma non small nonsmall non-small cells lungs breasts heads necks testicular vincristine tubulin microtubule assembky cycles arrest chemotherapy regimens bleomycin methotrexate VBM combination chemotherapy therapy catharanthus roseus vinca C. V. madagascar periwinkle analogs M phase mitotic spindle L-cell L 29060-LE 29060 LE alkaban AQ NSC-49842 NSC49842 velban
Product Overview:
Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM.{21119} Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.{21618}
Size 5 mg
Shipping dry ice
CAS Number 143-67-9
Molecular Formula C46H58N4O9 • H2SO4
SMILES CC[C@]1(O)C[C@@](C[N@@](CC2)C1)([H])C[C@](C(OC)=O)(C3=C(OC)C=C(N(C)[C@]4([H])[C@@]56[C@](N7CC6)([H])[C@](C=CC7)(CC)[C@@H](OC(C)=O)[C@]4(O)C(OC)=O)C5=C3)C8=C2C(C=CC=C9)=C9N8.O=S(O)(O)=O
Molecular Weight 909,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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