Tetrahydrocurcumin

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Tetrahydrocurcumin

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Cat No: 11757

Biochemicals - Ox Stress Reagents

Tetrahydrocurcumin is a metabolite of curcumin (Item Nos. 81025
81025.1) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties.{42115,38854,1467,42397} It scavenges 2,2-diphenyl-...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione

Correlated keywords:

HZIV-81-2 812 HZIV812 Tetrahydro-curcumin diferuloylmethane Tetrahydrodiferuloylmethane Sabiwhite NSC687845 AS-KTC-004 KTC004 ASKTC-004 ASKTC004 anti-cancer oxidant antiinflammatory antiangiogenic COX2 TNF? IL6 VEGFR-2 HIF1? THC lipopolysaccharide (for LPS-induced) turmeric Indian saffron

Product Overview:
Tetrahydrocurcumin is a metabolite of curcumin (Item Nos. 81025
81025.1) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties.{42115,38854,1467,42397} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay with an EC50 value of 16.8 μM.{42115} Tetrahydrocurcumin (50 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 expression in RAW 264.7 cells.{38854} It also inhibits LPS-induced increases in TNF-α release when used at a concentration of 100 µM and increases in nitric oxide (NO) production and IL-6 levels in a concentration-dependent manner. Tetrahydrocurcumin reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg).{1467} It also reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGF receptor 2 (VEGFR2), and hypoxia-inducible factor-1α (HIF-1α) expression in a CaSki cervical cancer nude mouse xenograft model when administered at doses of 100, 300, and 500 mg/kg.{42397}

Size	1 mg
Shipping	dry ice
CAS Number	36062-04-1
Molecular Formula	C₂₁H₂₄O₆
SMILES	OC1=C(OC)C=C(CCC(CC(CCC2=CC=C(O)C(OC)=C2)=O)=O)C=C1
Molecular Weight	372,4
Formulation	A crystalline solid
Purity	≥95% (mixture of tautomers)
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.