Neoandrographolide

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Neoandrographolide

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Cat No: 11742

Biochemicals - Natural Products

Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[2-[(1R,4aS,5R,8aS)-5-[(?-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone

Correlated keywords:

diterpenoid medicinal plant immunosuppression antithrombosis anti-inflammatory antineoplastic anti-viral anti-bacterial anti-diabetic anti-oxidative stress antipyretic anti-edematogenic anti-nociceptive endothelial cell inflammation furin inhibitor anti-thrombosis antiinflammatory anti-neoplastic antiviral antibacterial antidiabetic antioxidative antiedematogenic antinociceptive immunology infectious disease intracellular signaling biochemical natural product inhibit Andrographis paniculata A. paniculata therapeutic immunosuppressant antithrombotic anti-thrombotic LPS-induced nitric oxide production NO macrophage reduce VEGF-induced proliferation human umbilical vein pro-protein convertase neoandrographiside HUVEC cancer diterpine

Product Overview:
Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.{21112} Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).{28493} At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.{28494} Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.{28495}

Size	1 mg
Shipping	dry ice
CAS Number	27215-14-1
Molecular Formula	C₂₆H₄₀O₈
SMILES	C[C@]12[C@@](CCC([C@H]2CCC3=CCOC3=O)=C)([H])[C@@](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)(C)CCC1
Molecular Weight	480,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.