Muristerone A

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Muristerone A

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Cat No: 11741

Biochemicals - Receptor Pharmacology

Muristerone A is a natural analog of 20-hydroxyecdysone (Item No. 16145). It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development.{26923,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2?,3?,5?,11?,14,20,22R-heptahydroxy-cholest-7-en-6-one

Correlated keywords:

naturals products nuclear receptors agonists genes regulations hormones steroids endocrinology biochemical analogs 20-hydroxyecdysone ecdysteroid heterodimerizes retinoid X orthologs regulates arthropods development ecdysone-inducible ecdysone inducble expressions systems mammalian cells inhibitors inhibits inhibitions apoptosis humans colons carcinomas lines RKO inducing upregulations up-regulation up regulations Bcl-xL BclxL Bcl xL 37321-04-3

Product Overview:
Muristerone A is a natural analog of 20-hydroxyecdysone (Item No. 16145). It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development.{26923,26924,26920} Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells.{26921,26316} However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.{26922}

Size	250 µg
Shipping	dry ice
CAS Number	38778-30-2
Molecular Formula	C₂₇H₄₄O₈
SMILES	CC(C)CC[C@@H](O)[C@](C)(O)[C@@]1([H])CC[C@@]2(O)C3=CC([C@]4(O)C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])[C@H](O)C[C@@]21C)=O
Molecular Weight	496,6
Formulation	A solid
Purity	≥95%
Custom Code	2937.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.