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Oleanolic Acid

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    Oleanolic Acid
  • Oleanolic Acid
Cat No: 11726
Biochemicals - Natural Products
Cayman

Oleanolic acid is a pentacyclic triterpenoid that has been found in O. europaea and has diverse biological activities.{60738,60739,60740,60741,60742} It is active against S. aureus, B. thuringiensis, E. coli, S. enterica, and S. dysenteriae (MICs = 1....

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3?-hydroxy-olean-12-en-28-oic acid
Correlated keywords:
  • herbals medicines inflammation cancers viruses hyperlipidemia squalene antiinflammatory anti-inflammatory anti-hyperlipidemic antihyperlipidemic hepatoprotective in vivo antiviral anti-viral anti-tumors antitumor triterpenoids Michael addition Keap1 IKK JAK1 STAT3 PTEM proteins actin cytoskeleton oleonolic acid DU 145 MCF7 U 87 THP1 coculture super oxide cyto toxic Shigella Salmonella Escherichia Bacillus Staphylococcus Olea
Product Overview:
Oleanolic acid is a pentacyclic triterpenoid that has been found in O. europaea and has diverse biological activities.{60738,60739,60740,60741,60742} It is active against S. aureus, B. thuringiensis, E. coli, S. enterica, and S. dysenteriae (MICs = 1.9, 1.9, 7.8, 3.9, and 1.9 µg/ml, respectively) and scavenges hydroxyl and superoxide radicals in cell-free assays when used at a concentration of 1 mg/ml. Oleanolic acid is cytotoxic to DU145 prostate and MCF-7 breast cancer cells, as well as U87 glioblastoma cells, with IC50 values of 112.57, 132.29, and 163.6 µg/ml.{60740} It reduces LPS-induced adherence of THP-1 monocytes to human umbilical vein endothelial cells (HUVECs) in a co-culture model of monocyte-endothelial cell adhesion when used at concentrations ranging from 10 to 50 µM.{60741} Oleanolic acid (200 µmol/kg) decreases liver necrosis in several mouse models of liver injury, including those induced by acetaminophen (Item No. 10024), carbon tetrachloride (CCl4), or LPS/D-galactosamine.{60742}
Size 100 mg
Shipping dry ice
CAS Number 508-02-1
Molecular Formula C30H48O3
SMILES CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1
Molecular Weight 456,7
Formulation A crystalline solid
Purity ≥95%
Custom Code 2916.15
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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