Pellitorine

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Pellitorine

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Cat No: 11662

Biochemicals - Natural Products

Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities.{49685,49686,49687,49688} It induces mortality in C. pipiens pallens, A. aegypti, and A. togoi third instar larvae with LC50 values of 0.86, 0.92, ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2E,4E)-N-(2-methylpropyl)-2,4-decadienamide

Correlated keywords:

BRN 1725967 BRN1725967 Optaflow A trans pellitorin piper Culex Aedes HL60 MCF7 TNF? IL1? IL1? ERK HMGB 1 2

Product Overview:
Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities.{49685,49686,49687,49688} It induces mortality in C. pipiens pallens, A. aegypti, and A. togoi third instar larvae with LC50 values of 0.86, 0.92, and 0.71 ppm, respectively.{49686} Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively).{49687} It inhibits production of TNF-α, IL-1α, and IL-1β and phosphorylation of ERK1/2 induced by high mobility group protein B1 (HMGB1) in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 20 µM.{49688} Pellitorine (9 µg/animal, i.v.) prolongs survival time in a mouse model of sepsis induced by HMGB1.

Size	1 mg
Shipping	dry ice
CAS Number	18836-52-7
Molecular Formula	C₁₄H₂₅NO
SMILES	O=C(/C=C/C=C/CCCCC)NCC(C)C
Molecular Weight	223,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.