Heneicosapentaenoic Acid methyl

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Heneicosapentaenoic Acid methyl ester

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Cat No: 11622

Biochemicals - Lipids

Heneicosapentaenoic Acid (HPA) is a fatty acid present in trace amounts in the green algae Bryopsis pennata Lamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6Z,9Z,12Z,15Z,18Z-heneicosapentaenoic acid, methyl ester

Correlated keywords:

fatty acids EPA DHA arachidonic linoleic PGH synthases 5-LO prodrugs 5-LOX LO LOX prostaglandins PGs HPA Bryopsis pennata Lamouroux green algae fish oils eicosapentaenoic docosahexaenoic phospholipids 5-lipoxygenases 5 lipoxygenases

Product Overview:
Heneicosapentaenoic Acid (HPA) is a fatty acid present in trace amounts in the green algae Bryopsis pennata Lamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the Δ6 position.{5246} HPA can be used to study the significance of the position of the double bonds in n-3 fatty acids. It incorporates into phospholipids and into triacylglycerol in vivo with the same efficiency as EPA and docosahexaenoic acid (DHA) and exhibits strong inhibition of arachidonic acid synthesis from linoleic acid.{5246} HPA is a poor substrate for prostaglandin H (PGH) synthase and for 5-lipoxygenase but retains the ability to rapidly inactivate PGH synthase.{5246} In certain formulations, HPA methyl ester may serve as a prodrug, which should facilitate uptake of HPA and then be hydrolyzed by esterases to generate the free acid once incorporated into cells. It may also be useful as a reference standard in analytical work.

Size	1 mg
Shipping	dry ice
CAS Number	65919-53-1
Molecular Formula	C₂₂H₃₄O₂
SMILES	CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCC(OC)=O
Molecular Weight	330,5
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.