Temsirolimus

Confirm delete?

Temsirolimus

Zoom

Cat No: 11590

Biochemicals - Small Molecule Inhibitors

Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimu...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate] rapamycin

Correlated keywords:

cancers cells biology inhibitors inhibitions immunology signals transductions 343261-52-9 1034922-90-1 torisel Temsorolimus WAY-CCI 779 WAY-CCI-779 WAYCCI779 WAY CCI 779 CCI779 rapamycin immunosuppressants cytosolic FK-binding proteins 12 FKBP12 complexes mammals mammalian targets mTOR pathways Complex 1 I dihydroxymethyls propionic acids esters signalling signaling signals cycles arrests growth phases G1 G1-phase reduces reducing tumors angiogenesis synthesis VEGF cytostatic activity activities xenografts models humans nude mice mouse glioblastomas prostrates carcinomas pancreas pancreatic livers breasts medulloblastomas inhibitor-779 antitumors

Product Overview:
Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin.{22731} Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF.{22733,22730} Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.{22733,22732,22730,22731}

Size	1 mg
Shipping	dry ice
CAS Number	162635-04-3
Molecular Formula	C₅₆H₈₇NO₁₆
SMILES	O=C(O[C@](CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@@H](C1)C)=O)=O)([H])[C@H](C)C[C@@H]2CC[C@@H](OC(C(C)(CO)CO)=O)[C@H](OC)C2)[C@@]3([H])N(C(C([C@@]4(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C\[C@H]1C)OC)([H])O4)=O)=O)CCCC3
Molecular Weight	1030,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.