CI-1040

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CI-1040

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Cat No: 11580

Biochemicals - Kinase Inhibitors

The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} CI-1040 is a benzhydroxamate compound that potently inhibits MEK...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide

Correlated keywords:

PD184352 PD-184352 CI1040 CI 1040 MEKs inhibitors PD 0325901MAPKs ERKs cancers CI1040 CI 1040 benzhydroxamate inhibits inhibitions in vitro mitogen-activated mitogens activated proteins MAPs adenosine triphosphates tumors extracellular signal-regulated kinases signals regulated potent signaling intracellular transductions threonine methyl ethyl ketones RAS RAF pathways humans ATP phosphorylation mouse mice colons PD184352 PD-184352

Product Overview:
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.{6694,16830} CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate).{16877,15629} It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model.{16877} The second-generation MEK inhibitor PD 0325901 (Item No. 13034) is a structural derivative of CI-1040 that was developed for improved solubility.{16877}

Size	5 mg
Shipping	dry ice
CAS Number	212631-79-3
Molecular Formula	C₁₇H₁₄ClF₂IN₂O₂
SMILES	FC1=CC=C(C(NOCC2CC2)=O)C(NC3=C(Cl)C=C(I)C=C3)=C1F
Molecular Weight	478,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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