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HMGB1 Monoclonal Antibody (Clone IMG19N10B7)

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    HMGB1 Monoclonal Antibody (Clone IMG19N10B7)
  • HMGB1 Monoclonal Antibody (Clone IMG19N10B7)
Cat No: 11512
Cayman

High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficien...

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: 1 ea

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • high mobility groups proteins family DNA-binding domains inflammation mediators DNA nuclear bindings sterile infection-associated responses Toll-like receptor 4 TLR4 advanced glycation endproducts RAGE IHC immunohistochemistry Western blot blotting flow cytometry FC WB paraffin embedded tissues paraffin-embedded
Product Overview:
High Mobility Group Protein B1 (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).{20300} It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.{20304}
Size 1 ea
Shipping dry ice
Host Mouse
Antigen full length recombinant human HMGB1
Clone IMG19N10B7
Isotype IgG2b?
Application(s)

FC, IHC (paraffin-embedded tissue), and WB

Formulation 100 µg of Protein G purified IgG2bk in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Custom Code 3822.19
UNSPSC code 12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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