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CBX5 (human recombinant)

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    CBX5 (human recombinant)
  • CBX5 (human recombinant)
Cat No: 11235
Proteins - More Proteins

The heterochromatin protein 1 (HP1) family, which consists of three isoforms HP1α (CBX5), HP1β (CBX1) and HP1γ (CBX3) are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal c...

: 100 µg

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • epigenetics heterochomatin chromodomains histones H3K9 Chromoshadow domains HP-1 HP1? HP1 ? HP1s HP1? HP1? hinges domain SETDB1 methylation homodimerization DNA damage response DDR CBX1 CBX3 chromatin-associated proteins chromatin associated genes regulations formations CBX lysines 9 H3 H3K9me2 H3K9me3 methylated silencing CSD DDR
Product Overview:
The heterochromatin protein 1 (HP1) family, which consists of three isoforms HP1α (CBX5), HP1β (CBX1) and HP1γ (CBX3) are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain which connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX5 has been shown to recognize di- and tri-methylated lysine 9 on histone H3 (H3K9me2 and H3K9me3), with a preference for H3K9me3. Binding of CBX5 to methylated histones leads to gene silencing and heterochromatin formation.{20846,20874} H3K9 trimethylation by the methyltransferase SETDB1 creates a binding site for recruitment of CBX5, leading to chromatin condensation and gene silencing.{20845} The chromoshadow domain facilitates protein-protein interactions like homodimerization and recruitment of nuclear proteins involved in transcriptional regulation.{20843} The chromoshadow domain is also responsible for recruitment to sites of DNA damage, where CBX5 helps to reorganize chromatin as part of the DNA damage response system.{20844}
Size 100 µg
Shipping dry ice
Formulation 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol
Purity ≥95% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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