DYn-2

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DYn-2

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Cat No: 11220

Biochemicals - More Biochemicals

Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH).{20734} Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a c...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-(pent-4-yn-1-yl)cyclohexane-1,3-dione

Correlated keywords:

oxidative stress cells signaling click chemistry, redox sulfenic acids probes reporters proteins

Product Overview:
Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH).{20734} Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells.{20729} DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications.{20729} The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.{20733}

Size	1 mg
Shipping	dry ice
CAS Number	1354630-46-8
Molecular Formula	C₁₁H₁₄O₂
SMILES	O=C1CCC(CCCC#C)C(C1)=O
Molecular Weight	178,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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