Prolyl-glycyl-proline Peptide

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Cat No: 11188

Biochemicals - Peptides

Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).{20330} PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cle...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

LTA4 hydrolases substrates COPD cystic fibrosis neutrophils infiltration CF MMP-8 MMP-9 CXCR1 CXCR2 chemoattractants

Product Overview:
Proline-glycine-proline (PGP) is a tripeptide molecule and an established biomarker for chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).{20330} PGP functions as a neutrophil chemoattractant and is derived from the proteolytic cleavage of collagen in the extracellular matrix by a multistep cascade. First, the matrix metalloproteases MMP-8 or MMP-9 cleave collagen to peptides 30-100 amino acids in length. Prolyl endopeptidase further cleaves the collagen fragments to PGP. PGP and the related peptide N-acetylated PGP (Item No. 11189) act through chemokine receptors CXCR1 and CXCR2 on neutrophil cells.{20331} Patients with cystic fibrosis have been shown to have elevated levels of PGP peptides in sputum.{20330} PGP, but not N-acetylated PGP, has been demonstrated to be a substrate for the pro-inflammatory enzyme LTA4 hydrolase.{20329}

Size	5 mg
Shipping	dry ice
Molecular Weight	269,3
Formulation	A lyophilized powder
Purity	≥95% by HPLC
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.