1,25-dihydroxy Vitamin D2

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1,25-dihydroxy Vitamin D₂

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Cat No: 11174

Biochemicals - Receptor Pharmacology

1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.{20502} By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activate...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1R,3S,5Z)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol

Correlated keywords:

vitamins D receptors calcium calcitriol calcipotriol retinoid X metabolites liver kidneys VDR RXR genes transcription dihydroxyergocalciferol Ro-176218 Ro 176218 agonist

Product Overview:
1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.{20502} By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.{20503} Because 1,25-dihydroxy Vitamin D2 circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify.{20502}

Size	500 µg
Shipping	dry ice
CAS Number	60133-18-8
Molecular Formula	C₂₈H₄₄O₃
SMILES	O[C@H]1C[C@H](O)C(/C(C1)=C\C=C2CCC[C@@]3(C)[C@@]/2([H])CC[C@]3([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C)=C
Molecular Weight	428,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2936.29
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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