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2,4-Pyridinedicarboxylic Acid (hydrate)

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    2,4-<wbr/>Pyridinedicarboxylic Acid (hydrate)
  • 2,4-<wbr/>Pyridinedicarboxylic Acid (hydrate)
Cat No: 11138
Biochemicals - Small Molecule Inhibitors
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxy...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 2,4-pyridinedicarboxylic acid, monohydrate
Correlated keywords:
  • 499-80-9 NSC 403248 NSC403248 Pyridine di carboxylate lutidinic PD CA 24PDCA 2OG keto glutarate
Product Overview:
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl).{23686,23688} 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations.{23695,20945,23687} Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation.{23686,18511} It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.{23684} 2,4-PDCA also affects and is translocated by organic anion transporters.{23689}
Size 1 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 207671-42-9
Molecular Formula C7H5NO4 • H2O
SMILES OC(C1=NC=CC(C(O)=O)=C1)=O.O
Molecular Weight 185,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.39
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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