2,4-Pyridinedicarboxylic Acid (h

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2,4-Pyridinedicarboxylic Acid (hydrate)

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Cat No: 11138

Biochemicals - Small Molecule Inhibitors

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxy...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,4-pyridinedicarboxylic acid, monohydrate

Correlated keywords:

499-80-9 NSC 403248 NSC403248 Pyridine di carboxylate lutidinic PD CA 24PDCA 2OG keto glutarate

Product Overview:
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl).{23686,23688} 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations.{23695,20945,23687} Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation.{23686,18511} It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.{23684} 2,4-PDCA also affects and is translocated by organic anion transporters.{23689}

Size	1 g
Shipping	dry ice
CAS Number	207671-42-9
Molecular Formula	C₇H₅NO₄ • H₂O
SMILES	OC(C1=NC=CC(C(O)=O)=C1)=O.O
Molecular Weight	185,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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MSDS

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