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Nicotinamide

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    Nicotinamide
  • Nicotinamide
Cat No: 11127
Biochemicals - Natural Products
Cayman
€25.00
Price is excluding VAT and does not include packaging neither shipping

Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet.{63061} It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1;...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-pyridinecarboxamide
Correlated keywords:
  • 37321-14-5 78731-47-2 123574-63-0 3-Aminocarbonylpyridine Amidopyridine Carbamoylpyridine Pyridinecarboxylic Aminicotin Benicot Delonin Dipegyl NAM Niavit-PP Nicamina Nicamindon Nicasir Nicobion Nicofort Nicosan 2 Nicosylamide Nicotilamide Nicotine Nicotylamide Nicovit Nicovitina Nictoamide Niocinamide Niozymin NSC13128 NSC27452 Papulex Pelmin Pelmine Pelonin Vi-Nicotyl β-Pyridine-carboxamide SIRT-1 SNU398 SNU739 Hep-G2
Product Overview:
Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet.{63061} It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM).{63062} Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes.{63063} Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC.{63064} Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.{63065,63066,63067}
Size 25 mg
Shipping dry ice
CAS Number 98-92-0
Molecular Formula C6H6N2O
SMILES O=C(N)C1=CC=CN=C1
Molecular Weight 122,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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