Suramin (sodium salt)

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Cat No: 11126

Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM)....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt

Correlated keywords:

145-63-1 90586-65-5 African sleeping sickness anti-trypanosomal antitrypanosomal anti trypanosomals trypans derivatives Bayer 205 bayer-205 antiproliferatives anti-proliferatives proliferatives Germanin inhibitors inhibits inhibitions calmodulin antagonists P2 purinergic receptors glycosaminoglycan anticancers antivirals cancers anti-cancers viral anti-virals polysulfonated naphthylurea binding binds binders ryanodine receptor-1 blocks blocking blockers G proteins G-proteins coupling GPCRs non-specific non specific competitors TGF? PDGF FGF insulin-like insulin growth factors factor-1 EGF PKC activity PKC TNF IL-2 IL IL2 transferrin Apo-B apoB Apo B blindness blind sick sleeps onchocerciasis cells lines lungs breast horomes refractory prostates metastatic renalcolorectal high-grades high grades gliomas agents mechanisms actions BAY-205 BAYs 205 BAY205 CL 1003 CI1003 CI-1003 fourneau 309 fourneau-309 germanin hexasodium carbamides moranyl NF060 NF-060 NFs 060 naganin naganines naphurides sodiums 90586-65-5 interleukins tumors necrosis TGF.beta. TGFB TGFb treatments river clinical evaluations regress Leishmania

Product Overview:
Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM).{23034,23035} Suramin also acts as a non-specific competitor of glycosaminoglycan binding to a variety of targets including TGFβ, PDGF, and FGF and additionally inhibits insulin-like growth factor-l, EGF, PKC activity, TNF, IL-2, transferrin, and Apo-B.{20120} While originally used as an early stage treatment of trypanosome-caused onchocerciasis (African river blindness) and African trypanosomiasis (African sleeping sickness), suramin has been under clinical evaluation for its potential to regress a number of cancer cell lines, including non-small cell lung cancer, advanced breast cancer, hormone refractory prostate cancer, metastatic renal cell cancer, colorectal cancer, and high-grade gliomas.{20120,20123,20121}

Size	100 mg
Shipping	room temp.
CAS Number	129-46-4
Molecular Formula	C₅₁H₃₄N₆O₂₃S₆ • 6Na
SMILES	O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Molecular Weight	1429,1
Formulation	A solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.