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Suramin (sodium salt)

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    Suramin (sodium salt)
  • Suramin (sodium salt)
Cat No: 11126

Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM)....


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Territorial Availability: Available through Bertin Technologies only in France
  • 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt
Correlated keywords:
  • 145-63-1 90586-65-5 African sleeping sickness anti-trypanosomal antitrypanosomal anti trypanosomals trypans derivatives Bayer 205 bayer-205 antiproliferatives anti-proliferatives proliferatives Germanin inhibitors inhibits inhibitions calmodulin antagonists P2 purinergic receptors glycosaminoglycan anticancers antivirals cancers anti-cancers viral anti-virals polysulfonated naphthylurea binding binds binders ryanodine receptor-1 blocks blocking blockers G proteins G-proteins coupling GPCRs non-specific non specific competitors TGF? PDGF FGF insulin-like insulin growth factors factor-1 EGF PKC activity PKC TNF IL-2 IL IL2 transferrin Apo-B apoB Apo B blindness blind sick sleeps onchocerciasis cells lines lungs breast horomes refractory prostates metastatic renalcolorectal high-grades high grades gliomas agents mechanisms actions BAY-205 BAYs 205 BAY205 CL 1003 CI1003 CI-1003 fourneau 309 fourneau-309 germanin hexasodium carbamides moranyl NF060 NF-060 NFs 060 naganin naganines naphurides sodiums 90586-65-5 interleukins tumors necrosis TGF.beta. TGFB TGFb treatments river clinical evaluations regress Leishmania
Product Overview:
Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM).{23034,23035} Suramin also acts as a non-specific competitor of glycosaminoglycan binding to a variety of targets including TGFβ, PDGF, and FGF and additionally inhibits insulin-like growth factor-l, EGF, PKC activity, TNF, IL-2, transferrin, and Apo-B.{20120} While originally used as an early stage treatment of trypanosome-caused onchocerciasis (African river blindness) and African trypanosomiasis (African sleeping sickness), suramin has been under clinical evaluation for its potential to regress a number of cancer cell lines, including non-small cell lung cancer, advanced breast cancer, hormone refractory prostate cancer, metastatic renal cell cancer, colorectal cancer, and high-grade gliomas.{20120,20123,20121}
Size 100 mg
Shipping room temp.
CAS Number 129-46-4
Molecular Formula C51H34N6O23S6 • 6Na
SMILES O=C(C1=CC=C(C)C(NC(C2=CC(NC(NC3=CC(C(NC4=C(C)C=CC(C(NC5=C(C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C6)C6=C(S(=O)([O-])=O)C=C5)=O)=C4)=O)=CC=C3)=O)=CC=C2)=O)=C1)NC7=CC=C(S(=O)([O-])=O)C8=C7C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C8.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Molecular Weight 1429,1
Formulation A solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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