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Nifedipine

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    Nifedipine
  • Nifedipine
Cat No: 11106
Biochemicals - Ion Channel Modulation
Cayman
€20.00
Price is excluding VAT and does not include packaging neither shipping

Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in...

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester
Correlated keywords:
  • dihydropyridine Ca2+ hypertension angina endothelia cardiology preterm labor Raynaud’s phenomenon pulmonary edema coronary vasodilator antioxidant 11104-22-6 101539-70-2 101554-38-5 adalat nifediac cordipin procardia nifedical adalate adapine adapress alat alfadat alonix angipec anifed BAY-1040 BAY1040 BAY-a BAYa BAY-a 1040 bonacid calcigard calcibloc calciguard calcilat camont cardifen cardionorm chronadalate coral cordafen cordaflex cordilan corinfar corotrend corynphar depin dignokonstant dilafed dilcor duranifin ecodipin fedcor fenamon fedipin fenihidine glopir hadipine hexadilat introcar kordafen macorel megalat myogard nifedilat nifedirex nifelantern nifelat nifensar niphedipine nyefax orix oxcord pidilat procardia sepamit TN 873R TN-873R TN873R tensopin tibricol UV-ENP 349PINa vasdalat vasofed xinran zenusin
Product Overview:
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Size 1 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 21829-25-4
Molecular Formula C17H18N2O6
SMILES CC1=C(C(OC)=O)C(C(C(OC)=O)=C(C)N1)C2=CC=CC=C2[N+]([O-])=O
Molecular Weight 346,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.39
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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