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BRD4 bromodomains 1 and 2 (human, recombinant; aa 49-460)

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    BRD4 bromodomains 1 and 2 (human, recombinant; aa 49-460)
  • BRD4 bromodomains 1 and 2 (human, recombinant; aa 49-460)
Cat No: 11052
Proteins - More Proteins
Cayman
€418.00
Price is excluding VAT and does not include packaging neither shipping

Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) family.{33144} It is a ubiquitously expressed nuclear protein with roles in a variety of cellular processes, including regulation of gene transcript...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • BRD 2 3 4 IBET anti-viral SARS-CoV-2 SARSCoV2 covid-19 covid19 coronavirus corona virus
Product Overview:
Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) family.{33144} It is a ubiquitously expressed nuclear protein with roles in a variety of cellular processes, including regulation of gene transcription, cell cycle progression, and viral genome segregation.{33144,49639} BRD4 is comprised of two N-terminal bromodomains (BD1 and BD2) that can bind to acetylated lysine residues in histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, an extra-terminal (ET) domain that facilitates protein-protein interactions, and a C-terminal motif, and can be expressed as either a long or short isoform generated via alternative splicing.{33144,49639,49640} In addition to binding acetylated lysine residues on histones, BRD4 can bind to a variety of non-histone proteins and protein complexes, including positive transcription elongation factor b (P-TEFb) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein, a transmembrane protein involved in CoV virion assembly and pathogenesis of the related virus, SARS-CoV.{33144,55024,53462,49521} In mice, knock-down of Brd4 is embryonic lethal.{49639} Chromosomal translocations leading to the fusion of BRD4 with the nuclear protein in testis (NUT) gene and resulting in expression of BRD4-NUT fusion proteins are associated with NUT midline carcinoma (NMC).{33144,49640} Inhibition of BRD4-NUT binding to chromatin by the BET bromodomain inhibitor (+)-JQ1 (Item No. 11187) induces tumor regression and prolongs survival in NMC mouse xenograft models.{19004} Cayman’s BRD4 bromodomains 1 and 2 (human, recombinant; aa 49-460) protein can be used for ELISA, Western blot (WB), and binding assay applications.
Size 100 µg
Shipping dry ice
Formulation 50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol
Purity ≥70% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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