7?,25-dihydroxy Cholesterol

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Cat No: 11032

Biochemicals - Lipids

GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody productio...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,7?)-cholest-5-ene-3,7,25-triol

Correlated keywords:

receptors agonists immunology chemokines autoimmune diseases 7?,25-OHC GPR183 GPR-183 GPRs 183 Epstein-Barr virus-induced genes 2 epstein barr virus induced two EBI-2 EBIs EBI2 5-cholesten-3?,7?,25-triol, oxysterol chemoattractant B-cell migration immune responses B cells LXR GPCR G-protein-coupled receptors proteins G coupled dihydroxycholesterol orphan spleens humoral antibody antibodies in vitro vivo

Product Overview:
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.{19918,19919} 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).{19918,19919} At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.{19919} 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.{19918,19919}

Size	1 mg
Shipping	dry ice
CAS Number	64907-22-8
Molecular Formula	C₂₇H₄₆O₃
SMILES	O[C@@H]1C=C2C[C@@H](O)CC[C@]2(C)[C@]3([H])[C@]1([H])[C@@](CC[C@]4([H])[C@H](C)CCCC(C)(C)O)([H])[C@]4(C)CC3
Molecular Weight	418,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.99
UNSPSC code	41116104

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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