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7α,25-dihydroxy Cholesterol

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    7α,25-<wbr/>dihydroxy Cholesterol
  • 7α,25-<wbr/>dihydroxy Cholesterol
Cat No: 11032
Biochemicals - Lipids
Cayman
€74.00
Price is excluding VAT and does not include packaging neither shipping

GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody productio...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (3β,7α)-cholest-5-ene-3,7,25-triol
Correlated keywords:
  • receptors agonists immunology chemokines autoimmune diseases 7α,25-OHC GPR183 GPR-183 GPRs 183 Epstein-Barr virus-induced genes 2 epstein barr virus induced two EBI-2 EBIs EBI2 5-cholesten-3β,7α,25-triol, oxysterol chemoattractant B-cell migration immune responses B cells LXR GPCR G-protein-coupled receptors proteins G coupled dihydroxycholesterol orphan spleens humoral antibody antibodies in vitro vivo
Product Overview:
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.{19918,19919} 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).{19918,19919} At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.{19919} 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.{19918,19919}
Size 1 mg
Shipping dry ice
CAS Number 64907-22-8
Molecular Formula C27H46O3
SMILES O[C@@H]1C=C2C[C@@H](O)CC[C@]2(C)[C@]3([H])[C@]1([H])[C@@](CC[C@]4([H])[C@H](C)CCCC(C)(C)O)([H])[C@]4(C)CC3
Molecular Weight 418,7
Formulation A crystalline solid
Purity ≥95%
Custom Code 2932.99
UNSPSC code 41116104

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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