Dexamethasone

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Dexamethasone

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Cat No: 11015

Biochemicals - Lipids

Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transact...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-fluoro-11?,17,21-trihydroxy-16?-methyl-pregna-1,4-diene-3,20-dione

Correlated keywords:

steroids hormones glucocorticoid agonist receptors inflammation genes expression anti-inflammatory antiinflammatory anti inflammatory 8054-59-9 137098-19-2 906362-70-7 906422-84-2 1050677-47-8 adexone aeroseb-Dex aphtasolon aphthasolone azium calonat corsone cortisumman decacort decaderm decadron A decalix decasone dekacort dekort delipos deltafluorene dergramin deronil desadrene desameton deseronil dexa-cortidelt dexa-mamallet dexa-scheroson dexa-sine dexacort dexacortal dexacortin dexadeltone dexafarma dexalona dexaltin dexameth dexamethasone alcohol dexamonozon dexapolcort dexapos dexaprol dexason dexasone dexinoral dexmethsone dexone dexonium dextelan dinomon diodex etacortilen fluormone fluorocort gammacorten gentalipos HL-dex hexadecadrol hexadrol isopto-dex lokalison F loverine luxazone MK-125 MK125 maxidex millicorten NSC-34521 NSC34521 oradexon pet-derm III posurdex prednisolon F prednisolone superprednol surodex visumetazone

Product Overview:
Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).{20150} Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.{20149}

Size	500 mg
Shipping	dry ice
CAS Number	50-02-2
Molecular Formula	C₂₂H₂₉FO₅
SMILES	O=C1C=C[C@]2(C(CC[C@]3([H])[C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@]4(O)C(CO)=O)C)[H])C)O)F)=C1)C
Molecular Weight	392,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.