1-NA-PP1

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1-NA-PP1

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Cat No: 10954

Biochemicals - Kinase Inhibitors

1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Correlated keywords:

inhibitors inhibits inhibition kinases mutated analogs sensitive v-Src vSrc c-Fyn cFyn Cdk2 c-Abl cAbl mammalian yeast 1NMPP1 1NA-PP1 cells permeable tyrosine cell-permeable AS Src-family Src I338G v-Src-AS1

Product Overview:
1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 1.5 nM versus 1.0 μM, respectively).{17286} The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 1.5 nM for c-Fyn-as1 versus 0.6 μM for c-Fyn; 7.0 nM for c-Abl-as2 versus 0.6 μM for c-Abl; 15 nM for Cdk2-as1 versus 18 μM for Cdk2).{17287} This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.{17287,20028,20029}

Size	1 mg
Shipping	dry ice
CAS Number	221243-82-9
Molecular Formula	C₁₉H₁₉N₅
SMILES	NC1=C(C(C2=C(C=CC=C3)C3=CC=C2)=NN4C(C)(C)C)C4=NC=N1
Molecular Weight	317,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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