SUCNR1 Polyclonal Antibody

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Cat No: 10928

SUCNR1 is a 334 amino acid-containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell commun...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

membranes receptors G-proteins coupled 1 family cells communications citric acids cycles succinate developments injury angiogenic factors VEGF proliferative ischemic retinopathy diabetic Western blots blotting immunohistochemistry IHC WB SUCNR-1 SUCNRs

Product Overview:
SUCNR1 is a 334 amino acid-containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication.{19519,19520} SUCNR1 is a receptor for the citric acid cycle intermediate succinate. It functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors, including VEGF, and also is involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases that stem from aberrant neovascularization in the mature retina such as diabetic retinopathy. Expression of SUCNR1 is common in kidney, liver, retina, platelets, and leukocytes.

Size	1 ea
Shipping	wet ice
Host	Rabbit
Antigen	Portion of amino acids 100-150 of human SUCNR1
Application(s)	IHC and WB
Formulation	100 µg in 200 µl of PBS containing 0.05% BSA and 0.05% sodium azide
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.