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Autotaxin (human, recombinant)

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    Autotaxin (human, recombinant)
  • Autotaxin (human, recombinant)
Cat No: 10803
Proteins - Enzymes

Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D (lysoPLD) that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which has roles in cell proliferation, survi...

: 100 µg

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • lyso PLD phosphatidylcholine phosphatidyl choline phosphatidic phospholipase phospho lipase diesterase COVID19
Product Overview:
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D (lysoPLD) that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which has roles in cell proliferation, survival, and migration.{19275} It is synthesized as a zymogen and is composed of a N-terminal signal peptide, which is cleaved during maturation, two somatomedin B-like domains, a phosphodiesterase (PDE) catalytic domain, and a C-terminal nuclease-like domain.{19280,60896} It is constitutively active and inhibited by LPA in a negative feedback loop.{60897,60898} Autotaxin is secreted primarily by adipose tissue and endothelial cells and has been found in numerous biological fluids, including the blood, cerebrospinal fluid, and saliva. It is overexpressed in a variety of cancers, including glioblastoma multiforme, melanoma, and hepatocarcinoma.{60897,60898,60899} Autotaxin has roles in cell motility, immune regulation, and embryogenesis.{60897,60898} Knockout of Enpp2 is embryonic lethal in mice.{60897} Autotaxin activity is increased in the serum of patients with a variety of conditions, including rheumatoid arthritis, chronic hepatitis C, or cholestasis, and serum autotaxin levels are increased in patients with asthma, acute respiratory distress syndrome (ARDS), or coronavirus disease 2019 (COVID-19).{60896,60900} Formulations containing autotaxin inhibitors have been used in clinical trials for the treatment of various diseases, including idiopathic pulmonary fibrosis (IPF), metabolic disorders, and cancer.{60900} Cayman’s Autotaxin (human, recombinant) protein can be used for enzyme activity assays.
Size 100 µg
Shipping dry ice
Host Insect cells
Formulation 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol
Purity ≥90% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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