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Autotaxin (human recombinant)

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    Autotaxin (human recombinant)
  • Autotaxin (human recombinant)
Cat No: 10803
Proteins - Enzymes
Cayman
€535.00
Price is excluding VAT and does not include packaging neither shipping

Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces various cellular r...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • lipids hydrolysis lysophophatidyl choline lysophophatidic acids secreated glycosylated active
Product Overview:
Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces various cellular responses.{19274} ATX-LPA signaling is involved in a range of pathologies including tumor progression and inflammation.{19278} ATX is proteolytically processed by cleavage of a 35 amino acid signal peptide and then secreted as a mature protein.{19280} N-glycosylation of ATX at Asn53 and Asn410 is essential for activity and secretion of ATX from adipocytes.{19274} ATX is organized in a modular domain arrangement with a central phosphodiesterase catalytic site, which is similar to the catalytic domain of alkaline phosphatases.{19275} Two cysteine-rich somatomedin B-like domains (involved in protein-protein interactions) are located at the N-terminal portion of the protein followed by an adjacent hydrophobic-containing RGD tripeptide motif that may be involved in cell-extracellular matrix interactions. Finally, a nuclease-like domain is located at the C-terminus, which is catalytically inert and possibly involved in substrate binding and presentation.{19277}
Size 100 µg
Shipping dry ice
Stability Store at -80 degrees; shelf life 270 days
Formulation 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Purity ≥90% estimated by SDS-PAGE
Custom Code 3822.00
UNSPSC code 12352203

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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